Fig. 5.

Establishment and test of the 14-gene diagnosis model. A, B. 14 circulating DE-IRGs were identified as diagnostic biomarkers by LASSO method. C, D. ROC curves evaluated the diagnostic effect of the 14 genes: CCR9 (AUC = 0.686), CER1 (AUC = 0.604), CSF2 (AUC = 0.688), CXCL2 (AUC = 0.589), HTR3C (AUC = 0.699), IL13RA1 (AUC = 0.650), IL1A (AUC = 0.667), INSL5 (AUC = 0.624), MBL2 (AUC = 0.619), MMP9 (AUC = 0.649), MSR1(AUC = 0.679), NR4RA2(AUC = 0.657), NTS(AUC = 0.667) and TNFRSF19 (AUC = 0.686). E. ROC curves analysis of training set for the diagnostic model including the 14 genes above (AUC = 0.968). F. ROC curves analysis of test set for the diagnostic model including the 14 genes above (AUC = 0.859)