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. Author manuscript; available in PMC: 2022 Sep 5.
Published in final edited form as: Brain Behav Immun. 2020 Jan 27;87:455–464. doi: 10.1016/j.bbi.2020.01.016

Fig. 1.

Fig. 1.

RSV dose-dependently inhibits CFA-induced TMJ inflammation. (A and B) Bilateral injection of CFA robustly decreased head withdrawal threshold in both sides of trigeminal nerve V3 branch-innervated facial skin area. (C and D) i.p. injection of RSV (40 mg/kg and 80 mg/kg) dose-dependently increased the CFA-decreased head withdrawal threshold compared to the DMSO treatment. As a control, RSV alone at high dose (80 mg/kg) had no effect on the head withdrawal threshold in animals not receiving CFA. In (A and B), *P < 0.05, **P < 0.01, P < 0.001 vs. the Saline group at corresponding time points; In (C and D), ++P < 0.01, +++P < 0.001 vs. the “Saline + DMSO” group at corresponding time points, and #P < 0.05, ##P < 0.01, ###P < 0.001 vs. the “CFA + DMSO” group at corresponding time points. (n = 6 per group).