Fig. 5.
RSV rescues BBB integrity after CFA injection. (A) The BBB integrity in the control mice treated with saline (intra-TMJ) and DMSO (i.p.) was normal and no Evans blue signal was shown in the brainstem sections. (B) CFA injection produced extravasation of Evans blue in the brainstem. (C) RSV treatment (40 mg/kg) completely blocked the CFA-caused BBB leakage. Scale bar, 50 μm. (D) Statistical analysis of percentage of Evans blue extravasated area to the whole image area. ***P < 0.001 as indicated in the figure (n = 3 per group). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)