FIG. 4.

Schematic diagram of the proposed topology of TMS 5 from the TetA(K) polypeptide (9); residues comprising motif C are depicted in reverse type. Shown at the bottom is a helical-wheel projection of 18 amino acid residues from TetA(K) TMS 5 created using the Helicalwheel program of the Genetics Computer Group package (5). Each residue within the helical wheel is offset from the preceding one by 100°; hydrophobic amino acids are boxed. The glycine-rich face of TMS 5 is indicated by the semicircle.