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. 2022 Sep 5;33(9):63. doi: 10.1007/s10856-022-06683-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The characterization of TNT and TNT-CIN. a The FTIR result showed characteristic groups after each reaction step, indicating the successful synthesis of TNT-CIN. b Cumulative release curve of CIN showed that the acidic microenvironment enhanced the release rate of TNT-CIN in the first few hours. c The surface topography observed by SEM demonstrated that TNT-CIN retained the nanotube structure. d The roughness (Sa and Sq) did not significantly differ between TNT and TNT-CIN either. e The hydrophilicity of TNT-CIN was higher than that of TNT. **P < 0.01