Table 3.
Log Neutralizing Antibody Titers by Vector dose and Incident Uveitis at Baseline, Day 7, Day 90 and Year 1
| Dose | Low | Medium | High | Higher | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| No Uveitis | Uveitis with No Symptom | No Uveitis | Uveitis with No Symptom | No Uveitis | Uveitis with No Symptom | No Uveitis | Uveitis with No Symptom | Uveitis with No Symptomatic | ||
|
| ||||||||||
| Visit Baseline | mean (SD) |
2.28 (1.79) |
4.31 (N/A) |
1.23 (1.04) |
1.90 (N/A) |
0.70 (0.00) |
4.31 (N/A) |
0.70 (0.00) |
0.70 (N/A) |
1.45 (0.90) |
| N | 8 | 1 | 8 | 1 | 2 | 1 | 2 | 1 | 4 | |
|
| ||||||||||
| mean | 2.35 | 4.31 | 1.23 | 4.31 | 1.30 | 4.31 | 0.70 | 0.70 | 1.75 (1.24) | |
| Day 7 | (SD) | (1.73) | (N/A) | (1.04) | (N/A) | (0.85) | (N/A) | (0.00) | (N/A) | |
| N | 8 | 1 | 8 | 1 | 2 | 1 | 2 | 1 | 4 | |
|
| ||||||||||
| mean | 2.51 | 4.31 | 1.23 | 4.31 | 1.30 | 4.31 | 0.70 | 3.11 | 3.71 (0.00) | |
| Day 90 | (SD) | (1.81) | (N/A) | (0.88) | (N/A) | (0.85) | (N/A) | (0.00) | (N/A) | |
| N | 7 | 1 | 8 | 1 | 2 | 1 | 1 | 1 | 1* | |
|
| ||||||||||
| mean | 2.59 | 1.47 | 4.31 | 1.00 | 4.31 | 1.30 | 0.70 | 3.11 (1.20) | ||
| Year 1 | (SD) | (1.72) | (0.97) | (N/A) | (0/3) | (N/A) | (0.85) | (N/A) | ||
| N | 7 | 7 | 1 | 2 | 1 | 2 | 1 | 3† | ||
*
Two patients missed 90-day visits due to the Covid19 pandemic
†
One patient had year 1 follow-up with an outside physician, due to the Covid 19 pandemic, and the test wasn’t done