. Author manuscript; available in PMC: 2023 Sep 1.

Published in final edited form as: Am J Ophthalmol. 2022 Mar 7;241:262–271. doi: 10.1016/j.ajo.2022.02.023

Table 4.

15 Letter ETDRS Visual Acuity Changes in 3 Study Groups and the Natural History Cohort

Group 1: Chronic bilateral group
Months		Study Eye			Fellow Eye

Followed	Dose	Worsened	Stable	Improved	Worsened	Stable	Improved

	Nat Hx	0 (0%)	19 (79%)	5 (21%)	1 (4%)	21 (88%)	2 (8%)
	Low	0 (0%)	3 (100%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)
12	Medium	0 (0%)	2 (67%)	1 (33%)	0 (0%)	2 (67%)	1 (33%)
	High	0 (0%)	1 (33%)	2 (67%)	0 (0%)	2 (67%)	1 (33%)
	Higher	0 (0%)	2 (100%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)

	Nat Hx	1 (5%)	13 (68%)	5 (26%)	0 (0%)	16 (84%)	3 (16%)
24	Low	0 (0%)	2 (67%)	1 (33%)	0 (0%)	2 (67%)	1 (33%)
	Medium	0 (0%)	2 (67%)	1 (33%)	0 (0%)	2 (67%)	1 (33%)
	High	0 (0%)	1 (33%)	2 (67%)	0 (0%)	2 (67%)	1 (33%)

	Nat Hx	0 (0%)	9 (82%)	2 (18%)	0 (0%)	10 (91%)	1 (9%)
36	Low	0 (0%)	2 (67%)	1 (33%)	0 (0%)	2 (67%)	1 (33%)
	Medium	0 (0%)	2 (67%)	1 (33%)	0 (0%)	2 (67%)	1 (33%)
Group 2: Acute Bilateral group
Months		Study Eye			Fellow Eye

Followed	Dose	Worsened	Stable	Improved	Worsened	Stable	Improved

	Nat Hx	2 (22%)	3 (33%)	4 (44%)	3 (33%)	3 (33%)	3 (33%)
12	Low	0 (0%)	1 (33%)	2 (67%)	1 (33%)	2 (67%)	0 (0%)
	Medium	0 (0%)	2 (100%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)
	Higher	1 (33%)	2 (67%)	0 (0%)	2 (67%)	1 (33%)	0 (0%)

	Nat Hx	1 (13%)	4 (50%)	3 (38%)	3 (38%)	3 (38%)	2 (25%)
24	Low	0 (0%)	0 (0%)	3 (100%)	0 (0%)	1 (33%)	2 (67%)
	Medium	0 (0%)	2 (100%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)
	Higher	1 (33%)	1 (33%)	1 (33%)	2 (67%)	0 (0%)	1 (33%)

	Nat Hx	1 (14%)	4 (57%)	2 (29%)	2 (29%)	4 (57%)	1 (14%)
36	Low	0 (0%)	0 (0%)	3 (100%)	0 (0%)	1 (33%)	2 (67%)
	Medium	0 (0%)	2 (100%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)
Group 3: Unilateral Acute Group
Months		Study Eye			Fellow Eye

Followed	Dose	Worsened	Stable	Improved	Worsened	Stable	Improved

	Nat Hx	1 (50%)	1 (50%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)
12	Low	3 (100%)	0 (0%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)
	Medium	3 (100%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)	0 (0%)
	Higher	2 (100%)	0 (0%)	1 (0%)	1 (50%)	1 (50%)	0 (0%)

	Nat Hx	1 (50%)	1 (50%)	0 (0%)	0 (0%)	1 (50%)	1 (50%)
24	Low	3 (100%)	0 (0%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)
	Medium	3 (100%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)	0 (0%)

	Nat Hx	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)
36	Low	3 (100%)	0 (0%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)
	Medium	3 (100%)	0 (0%)	0 (0%)	2 (67%)	1 (33%)	0 (0%)

Nat Hx = Natural History