Appendix Table 2.

Hazard ratio (HR) estimates for COVID-19-related outcomes by NRTI combination in men with HIV, Veterans Aging Cohort Study, February 2020 – October 2021

		No. events (up to 20 months)	Crude HR (95% CI)		Adjusted* HR (95% CI)
Documented SARS-CoV-2 infection	TAF/FTC	638	1 (ref.)		1 (ref.)
	TDF/FTC	30	0.59	(0.41, 0.85)	0.64	(0.44, 0.93)
	ABC/3TC	205	1.07	(0.91, 1.25)	1.03	(0.88, 1.20)
	Other	138	0.89	(0.74, 1.07)	0.85	(0.71, 1.03)
COVID-19 hospitalization	TAF/FTC	160	1 (ref.)		1 (ref.)
	TDF/FTC	5	0.39	(0.16, 0.96)	0.41	(0.17, 1.02)
	ABC/3TC	64	1.33	(0.99, 1.77)	1.15	(0.86, 1.54)
	Other	62	1.60	(1.20, 2.15)	1.15	(0.85, 1.57)
COVID-19 ICU admission	TAF/FTC	45	1 (ref.)		1 (ref.)
	TDF/FTC	2	0.57	(0.14, 2.35)	0.61	(0.15, 2.57)
	ABC/3TC	18	1.33	(0.77, 2.29)	1.00	(0.56, 1.76)
	Other	24	2.22	(1.35, 3.64)	1.51	(0.89, 2.55)

^*Adjusted for age, race/ethnicity, smoking status, CD4 cell count, HIV viral load, maximum HIV viral load over the past 12 months, BMI, systolic blood pressure, diastolic blood pressure, average eGFR over the past 12 months, months since February 2020, hospitalization in previous month, comorbidities including: cardiovascular disease, hypertension, liver disease, chronic pulmonary disease, cancer, chronic kidney disease, alcohol/substance use, diabetes, and dementia.

Abbreviations: 3TC – lamivudine; ABC – abacavir; FTC – emtricitabine; NRTI – nucleoside reverse transcriptase inhibitor; TDF – tenofovir disoproxil fumarate; TAF – tenofovir alafenamide; BMI – body mass index; eGFR – estimated glomerular filtration rate