Appendix Table 3.

Risks estimates for COVID-19-related outcomes by NRTI combination in men with HIV, with censoring at the time of death, Veterans Aging Cohort Study, February 2020 – October 2021

		No. events	18-month risk*, % (95% CI)		Risk difference, % (95% CI)		Risk ratio (95% CI)
Documented SARS-CoV-2 infection	TAF/FTC	621	7.8	(7.1, 8.4)	0 (ref.)		1 (ref.)
	TDF/FTC	28	5.1	(3.3, 7.0)	−2.6	(−4.5, −0.8)	0.66	(0.43, 0.89)
	ABC/3TC	201	7.8	(6.6, 8.9)	0.0	(−1.3, 1.3)	1.00	(0.84, 1.17)
	Other	134	7.0	(5.7, 8.2)	−0.8	(−2.3, 0.5)	0.90	(0.71, 1.07)
COVID-19 hospitalization	TAF/FTC	156	2.2	(1.8, 2.5)	0 (ref.)		1 (ref.)
	TDF/FTC	5	0.9	(0.2, 2.0)	−1.2	(−2.1, −0.2)	0.44	(0.07, 0.89)
	ABC/3TC	63	2.3	(1.7, 3.0)	0.2	(−0.5, 0.9)	1.08	(0.79, 1.48)
	Other	60	2.8	(2.0, 3.7)	0.7	(−0.1, 1.5)	1.31	(0.94, 1.76)
COVID-19 ICU admission	TAF/FTC	43	0.6	(0.4, 0.8)	0 (ref.)		1 (ref.)
	TDF/FTC	2	0.3	(0.0, 1.6)	−0.2	(−0.7, 1.1)	0.57	(0.00, 2.84)
	ABC/3TC	18	0.5	(0.3, 0.9)	0.0	(−0.3, 0.4)	0.93	(0.49, 1.82)
	Other	24	0.8	(0.5, 1.1)	0.2	(−0.2, 0.6)	1.38	(0.74, 2.44)

^*Standardized by age, race/ethnicity, smoking status, CD4 cell count, HIV viral load, maximum HIV viral load over the past 12 months, BMI, systolic blood pressure, diastolic blood pressure, average eGFR over the past 12 months, months since February 2020, hospitalization in previous month, comorbidities including: cardiovascular disease, hypertension, liver disease, chronic pulmonary disease, cancer, chronic kidney disease, alcohol/substance use, diabetes, and dementia.