Appendix Table 4.

Risks estimates for COVID-19-related outcomes by NRTI combination in men with HIV, without censoring at the time of vaccination against COVID-19, Veterans Aging Cohort Study, February 2020 – October 2021

		No. events	18-month risk*, % (95% CI)		Risk difference, % (95% CI)		Risk ratio (95% CI)
Documented SARS-CoV-2 infection	TAF/FTC	706	5.9	(5.4, 6.3)	0 (ref.)		1 (ref.)
	TDF/FTC	31	3.9	(2.7, 5.2)	−1.9	(−3.3, −0.7)	0.67	(0.46, 0.88)
	ABC/3TC	233	6.2	(5.5, 7.0)	0.4	(−0.5, 1.2)	1.06	(0.92, 1.22)
	Other	162	5.6	(4.7, 6.4)	−0.3	(−1.2, 0.6)	0.95	(0.80, 1.10)
COVID-19 hospitalization	TAF/FTC	175	1.6	(1.3, 1.8)	0 (ref.)		1 (ref.)
	TDF/FTC	6	0.7	(0.2, 1.3)	−0.9	(−1.4, −0.2)	0.45	(0.14, 0.84)
	ABC/3TC	69	1.7	(1.3, 2.1)	0.1	(−0.3, 0.6)	1.07	(0.80, 1.39)
	Other	68	1.9	(1.5, 2.3)	0.3	(−0.2, 0.8)	1.20	(0.91, 1.55)
COVID-19 ICU admission	TAF/FTC	47	0.4	(0.3, 0.6)	0 (ref.)		1 (ref.)
	TDF/FTC	2	0.2	(0.0, 0.7)	−0.2	(−0.5, 0.2)	0.48	(0.00, 1.51)
	ABC/3TC	21	0.5	(0.3, 0.7)	0.0	(−0.2, 0.3)	1.03	(0.60, 1.69)
	Other	28	0.7	(0.4, 1.0)	0.3	(0.0, 0.6)	1.62	(0.93, 2.62)

^*Standardized by age, race/ethnicity, smoking status, CD4 cell count, HIV viral load, maximum HIV viral load over the past 12 months, BMI, systolic blood pressure, diastolic blood pressure, average eGFR over the past 12 months, months since February 2020, hospitalization in previous month, comorbidities including: cardiovascular disease, hypertension, liver disease, chronic pulmonary disease, cancer, chronic kidney disease, alcohol/substance use, diabetes, and dementia.