Appendix Table 5.

Risks estimates for COVID-19-related outcomes by NRTI combination in men and women with HIV, Veterans Aging Cohort Study, February 2020 – October 2021

		No. events	18-month risk*, % (95% CI)		Risk difference, % (95% CI)		Risk ratio (95% CI)
Documented SARS-CoV-2 infection	TAF/FTC	638	7.4	(6.8, 8.0)	0 (ref.)		1 (ref.)
	TDF/FTC	29	4.9	(3.2, 6.6)	−2.5	(−4.3, −0.7)	0.66	(0.41, 0.90)
	ABC/3TC	208	7.5	(6.5, 8.6)	0.1	(−1.1, 1.3)	1.02	(0.86, 1.18)
	Other	136	6.4	(5.3, 7.5)	−1.0	(−2.2, 0.1)	0.86	(0.71, 1.02)
COVID-19 hospitalization	TAF/FTC	160	2.0	(1.6, 2.4)	0 (ref.)		1 (ref.)
	TDF/FTC	5	0.8	(0.2, 1.8)	−1.1	(−1.9, −0.1)	0.42	(0.11, 0.94)
	ABC/3TC	65	2.2	(1.6, 2.8)	0.2	(−0.4, 0.8)	1.10	(0.80, 1.46)
	Other	60	2.3	(1.7, 3.0)	0.3	(−0.4, 1.1)	1.17	(0.84, 1.59)
COVID-19 ICU admission	TAF/FTC	44	0.5	(0.4, 0.7)	0 (ref.)		1 (ref.)
	TDF/FTC	2	0.3	(0.0, 1.2)	−0.2	(−0.6, 0.7)	0.54	(0.00, 2.30)
	ABC/3TC	18	0.5	(0.3, 0.8)	0.0	(−0.3, 0.3)	0.91	(0.49, 1.62)
	Other	24	0.7	(0.4, 1.0)	0.2	(−0.1, 0.5)	1.30	(0.77, 2.21)

^*Standardized by age, race/ethnicity, smoking status, CD4 cell count, HIV viral load, maximum HIV viral load over the past 12 months, BMI, systolic blood pressure, diastolic blood pressure, average eGFR over the past 12 months, months since February 2020, hospitalization in previous month, comorbidities including: cardiovascular disease, hypertension, liver disease, chronic pulmonary disease, cancer, chronic kidney disease, alcohol/substance use, diabetes, and dementia.