Table 2.
Mean Number of Cells on AS-OCT Images by Manual Counting in Two Data Acquisition Protocols for 59 Eyes of 30 Children with Uveitis Involving the Anterior Segments.
| Clinical Grade of Cellsa | Single Line Protocolb Mean ± SD |
Radial Protocolb,c Mean ± SD |
Mean Difference Δ (95% Confidence Interval) |
|---|---|---|---|
| None (n=32) | 0.17 ± 0.7 | 0.11 ± 0.4 | −0.06 (−0.21, 0.09) |
| 0.5+ (n=12) | 0.88 ± 1.2 | 0.49 ± 0.9 | −0.38 (−0.98, 0.21) |
| 1+ (n=5) | 2.9 ± 2.3 | 1.4 ± 1.5 | −1.5 (−3.9, 0.9) |
| 2+ (n=8) | 9.7 ± 8.9 | 5.5 ± 5.0 | −4.2 (−10.2, 1.8) |
| 3+ (n=2) | 25.8 ± 9.1 | 22.0 ± 5.1 | −3.8 (−10.0, 2.5) |
Based on the Standardization of Uveitis Nomenclature grading system.4 Grades were assigned by one of three uveitis experts (ET, SMMF, GNH). No eye was assigned a grade of 4+.
Mean ± standard deviation, based on identification of hyper-reflective foci in the anterior chambers of each line scan. Counts represent the average of counts determined by two independent masked evaluators. There was no significant difference in rater reliability between acquisition modes (95% confidence interval for difference: −0.04 to 0.14), as determined by intraclass correlation (ICC). ICC differences between counts were evaluated using a bias-corrected bootstrap 95% confidence interval from 1,000 re-samplings.
The protocol includes 8 radial line scans. The mean is calculated from a summation of the counts assigned to all line scans.