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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Cancer Prev Res (Phila). 2022 Sep 1;15(9):581–594. doi: 10.1158/1940-6207.CAPR-22-0113

Figure 2.

Figure 2.

Calorie restriction promotes weight loss and reductions in adipokines in obese mice. (A) Weekly body weights were recorded for the control, obese, nonrestricted low-fat diet (LFD), low-fat calorie-restricted (LFCR), Mediterranean-style calorie-restricted (MCR), and intermittent calorie-restricted (ICR) mice. Final body weights (B) and body fat percentage (C) were measured just prior to euthanasia for all mice and 6 mice/group, respectively. (D) The average kcal/mouse/day consumed by each diet group was calculated for the time period between the end of week 15, when the diet switch occurred, and the end of study. (E) Insulin levels, (F) the leptin-adiponectin ratio, (G) insulin-like growth factor (IGF)-1 levels, (H) transforming growth factor beta 1 (TGF-β1) levels, (I) tumor necrosis factor alpha (TNFα) levels, and (J) interleukin 1 beta (IL-1β) levels were all measured in sera collected 1 week prior to tumor cell injections from 5–8 mice/group. *P<0.05, **P<0.01, ***P<0.001, all relative to the obese mice. #P<0.05, ##P<0.01, ###P<0.001, all relative to the nonrestricted LFD mice.