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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Cancer Prev Res (Phila). 2022 Sep 1;15(9):581–594. doi: 10.1158/1940-6207.CAPR-22-0113

Figure 5.

Figure 5.

Obesity reversal decreases global DNA methylation levels in normal mammary tissue. Pairwise comparisons of DNA methylation levels between (A) the obese and nonrestricted low-fat diet (LFD) groups, (B) the obese and low-fat calorie restricted (LFCR) groups, and (C) the obese and Mediterranean-style calorie restricted (MCR) groups are shown, expressed as the mean change in percent methylation and with a differentially methylated region (DMR) defined as a genomic site with an average absolute methylation value change of ≥15% and an FDR adjusted P<0.05 (n=3–5 mice/group). Locations of the DMR for each comparison, expressed as the number of DMR and percentage of DMR in each location, are also shown.