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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Cancer Prev Res (Phila). 2022 Sep 1;15(9):581–594. doi: 10.1158/1940-6207.CAPR-22-0113

Figure 6.

Figure 6.

Methylation of obesity-linked transcription factor binding sites is reduced by Mediterranean-style calorie restricted (MCR) diet. (A-B) Hypergeometric Optimization of Motif EnRichment (HOMER) analysis was used to identify enrichment in transcription factor binding motifs at the differentially methylated regions (DMR) for the obese versus MCR and obese versus nonrestricted low-fat diet (LFD) comparisons. (C) Ingenuity Pathway Analysis (IPA) prediction of upstream regulators was conducted for obese versus nonrestricted LFD, obese versus nonrestricted low-fat calorie restricted (LFCR), obese versus MCR, and obese versus intermittent calorie restricted (ICR) comparisons. (D) The top ten significant IPA functions (ranked by z-score) associated with differentially expressed genes (DEG) that contained ≥1 DMR (DEG+DMR) for the obese versus MCR comparison are shown. (E) Relative expression levels of the overlapping DEG+DMR for the obese versus LFCR and obese versus MCR comparisons are shown.