TABLE 3.

Difference in Vessel Density and Foveal Avascular Zone Parameters From Macular Scans After Timolol Use, After Latanoprostene Bunod Use, and Between Timolol and Latanoprostene Bunod Use

	Timolol vs Baseline	P Value	LBN vs Baseline	P Value	LBN vs Timolol	P Value
Vessel density (%) (95% CI)
Wi (wiVD)	−0.03 (−0.58 to 0.53)	.92	0.76 (0.20–1.33)	.009a	0.70 (0.10–1.29)	.02a
Wi superior hemi	−0.14 (−0.72 to 0.43)	.63	0.80 (0.22–1.38)	.007a	0.86 (0.25–1.47)	.006a
Wi inferior hemi	0.10 (−0.47 to 0.66)	.74	0.72 (0.14–1.29)	.02a	0.51 (−0.11 to 1.13)	.11
Para fovea	0.08 (−0.68 to 0.85)	.83	0.86 (0.05–1.66)	.04a	0.63 (−0.27 to 1.53)	.17
Para superior hemi	0.07 (−0.75 to 0.89)	.86	1.17 (0.32–2.02)	.007a	0.98 (0.02–1.93)	.047a
Para inferior hemi	0.10 (−0.71 to 0.91)	.81	0.54 (−0.35 to 1.43)	.24	0.28 (−0.70 to 1.26)	.57
Quadrant parafoveal vessel density (%) (95% CI)
Temporal	−0.09 (−0.91 to 0.73)	.83	0.81 (−0.03 to 1.64)	.06	0.70 (−0.22 to 1.63)	.14
Superior	−0.11 (−0.97 to 0.75)	.80	1.04 (0.10–1.97)	.03a	1.03 (0.02–2.05)	.048a
Nasal	0.22 (−0.73 to 1.16)	.66	0.87 (−0.11 to 1.86)	.08	0.56 (−0.58 to 1.70)	.34
Inferior	0.35 (−0.54 to 1.24)	.45	0.71 (−0.25 to 1.67)	.15	0.23 (−0.88 to 1.33)	.69
Foveal avascular zone (mm2) (95% CI)
Area	0.00 (−0.01 to 0.01)	.73	−0.00 (−0.01 to 0.01)	.90	−0.00 (−0.01 to 0.01)	.48
Perimeter	−0.01 (−0.04 to 0.03)	.69	−0.02 (−0.05 to 0.02)	.41	−0.01 (−0.05 to 0.03)	.53
FD 300 area density	0.17 (−0.69 to 1.02)	.77	0.26 (−0.60 to 1.11)	.56	0.09 (−0.95 to 1.13)	.87

CI = confidence interval; LBN = latanoprostene bunod; wi = whole image; FD 300 area density = density in the area within 300 μm from the foveal avascular zone boundary; VD =vessel density.

^aStatistically significant (P < .05).