Table 2:

Effects of Biomarkers on bDFS

		Unadjusted Model				Covariate-adjusted Modela
Variable	n/e	HR	95% CI	p-value	n/e	HR	95% CI	p-value
Log hsCRP	202/66	1.07	(0.84, 1.38)	0.58	202/66	1.07	(0.83, 1.38)	0.60
hsCRP dichotomized	201/65	0.95	(0.57, 1.57)	0.83	201/65	0.98	(0.59, 1.61)	0.92
Log CRP	202/66	1.05	(0.83, 1.33)	0.69	202/66	1.05	(0.83, 1.33)	0.70
Log IFN-γ	188/63	1.15	(0.87, 1.54)	0.33	188/63	1.15	(0.86, 1.55)	0.34
Log IL-1B	188/63	1.33	(0.99, 1.80)	0.063	188/63	1.33	(0.98, 1.79)	0.068
Log IL-2	188/63	1.20	(0.98, 1.46)	0.076	188/63	1.20	(0.98, 1.46)	0.08
Log IL-4	188/63	0.98	(0.77, 1.25)	0.89	188/63	0.98	(0.77, 1.25)	0.87
Log IL-5	187/63	1.24	(0.91, 1.69)	0.17	187/63	1.24	(0.91, 1.69)	0.17
Log IL-6	188/63	1.48	(1.03, 2.12)	0.033	188/63	1.50	(1.02, 2.19)	0.039
Log IL-8	188/63	1.02	(0.69, 1.52)	0.92	183/63	1.01	(0.68, 1.51)	0.94
Log IL-10	188/63	1.60	(1.17, 2.17)	0.0030	188/63	1.61	(1.18, 2.20)	0.0027
Log IL-12	188/63	1.28	(0.97, 1.69)	0.079	188/63	1.28	(0.97, 1.69)	0.080
Log IL-13	188/63	1.11	(0.94, 1.31)	0.20	188/63	1.12	(0.95, 1.32)	0.19
Log IL-17A	188/63	1.11	(0.87, 1.42)	0.40	188/63	1.11	(0.87, 1.42)	0.41
Log IL-23	188/63	1.11	(0.91, 1.35)	0.31	188/63	1.11	(0.91, 1.36)	0.30
MCP	187/63	1.02b	(0.81, 1.29)	0.86	187/63	1.02a	(0.80, 1.28)	0.89
Log TNF-α	188/63	0.96	(0.90, 1.03)	0.31	183/63	0.96	(0.89, 1.03)	0.25
Log GM-CSF	188/63	1.07	(0.91, 1.27)	0.40	188/63	1.07	(0.91, 1.26)	0.42

n/e: number of patients/number of events

^aModels for log(hsCRP), hsCRP dichotomized, and log(CRP) adjusted for treatment arm only; all others adjusted for treatment arm and log(CRP)

^bper one standard deviation (SD) change, SD=288