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A) Flow diagram of patient plasma availability and EGFR mutation positivity in ctDNA. Time course showing treatment-induced changes in EGFR MAF for B) all patients with a positive BL EGFR MAF and a C3D1 timepoint (n = 62), and C) for all patients with both C3D1 and PRG timepoints (right side, n = 46). Red lines indicate cases with residual ctDNA at C3D1; blue lines indicate cases with complete clearance at C3D1. The graph is log-transformed to highlight differences at low MAFs.
