Table 1:
Performance of model 1 and model 2 in Training set of Esophageal Brushings
| Performance of Individual markers | Model 1 | Model 2 | ||||||
|---|---|---|---|---|---|---|---|---|
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| # samples | Up10 | Up35-1 | cg6522 | YPEL3 | POU3F1 | Up10+Up35-1 + Cg6522+ YPEL3 | Prob_Cg6522+POU3F1 | |
| Cutoff for positivity | 0.01 | 0.01 | 40 | 2.5 | 12 | Cutoffs as for Individual markers | 0 45 | |
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| %Specificity SQ’s (95% Cl) | 48 | 100.0 | 100.0 | 97.9(93.8–100) | 100.0 | 100.0 | 97.9(93.8–100.0) | 85.4(74.6–96.2) |
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| %Specificity BE (95% Cl) | 19 | 100.0 | 84.2(66.3–100.0) | 100.0 | 100.0 | 100.0 | 84.2(66.3–100.0) | 94.7(84.4–100.0) |
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| %Sens LGD (95% Cl) | 20 | 20.0(2.0–38.0) | 35.0(0–70.0) | 5.0(0–47 7) | 15.0(0–37.1) | 25.0(0–63.0) | 50.0(19.0–81.0) | 45.0(12.5–77.5) |
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| %Sens HGD (9S% Cl) | 20 | 25.0(0.63.0) | 75.0(53.1–96.9) | 25.0(0–63.0) | 15.0(0–55.4) | 35.0(0–70.0) | 85.0(68.0–100.0) | 80.0(60.4–99.6) |
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| %Sens Early EAC (95% Cl) | 32 | 42.9(18.6–67.1) | 46.4(21.1–71.7) | 50.0(23.8–76.2) | 21.4(4.3–38.6) | 25.0(6.5–43.5) | 80.8(46.2–100.0) | 89.2(54.3–100.0) |
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| %Sens EAC (95% Cl) | 87 | 34.5(17.5–51.5) | 51.7(37.1–66.3) | 50.6(35.8–65.3) | 43.7(27.9–59.5) | 16.1(0–35.3) | 90.8(84.4–97.2) | 87.4(79.9–94.8) |