Table 2:

Performarvce of model 1 and model 2 In Validation set of Esophageal brushings

		Common core set of samples				Model 1	Model 2
	# samples	Up10	Up35-1	Cg6522	YPEL3	Up10+ Up35-1 + Cg522+ YPEL3	Prob_Cg6522+POU3F1
Cutoff		0.01	0.01	40	2.5	Cutoffs as for individual markers	0.45
%Specificity SQ’s (95% Cl)	27	100.0	100.0	100.0	96.3(89.0–100.6)	96.3 (89.0–100.0)	92.6(82.3–100.0)
%Specificity BE (95% Cl)	37	91 9(82.3–100.0)	83.8(70.8–96.8)	100 0(91.0–100.0)	91.9(82.7–100.0)	67.6(49.2–85.9)	83.8(70.8–96.8)
%Sens LGD (95% Cl)	10	10.0 (0–70.0)	30.0(0–80.0)	10.0(0–68.8)	10.0(0–68.0)	50(6.2–93.8)	40.(0–88.0)
%Sens HGD (95% Cl)	15	27.0(0–67.0)	60.0(28.0–92.0)	20.0(0–65.3)	13.0(0–59.9)	80(57.4–100.0)	67(37.9–96.1)
%Sens Early EAC (95% Cl)	12	60.0(11 9–100.0)	60.0(11.9–100.0)	20.0(0–47.7)	20.0(0–47.7)	70.0(18.1–100)	80.0(24.6–100.0)
%Sens EAC (95% Cl)	40	52.5(31 1–73.9)	40.0(16.0–64.0)	45.0(22.0–68.0)	35.0(10.0–60.0)	82.5(61.0–100.0)	82.5(69.5–95.5)