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. 2022 Jul 25;21(7):e12827. doi: 10.1111/gbb.12827

FIGURE 4.

FIGURE 4

Fear‐potentiated startle in WT and proSAAS KO mice. (A) Startle responses to the 100, 105 and 110 dB white noise stimuli during pre‐conditioning. A RMANOVA found only the main effects of dB on startle intensity [F (2,34) = 38.246, p < 0.001] to be significant. (B) FPS to the CS preceding the 100, 105, and 110 dB white noise stimuli examined 48 h after CS‐UCS pairings. For post‐conditioning, a RMANOVA detected significant effects of dB on startle intensity [F (2,34) = 30.033, p < 0.001] and genotype [F (1,17) = 5.586, p = 0.030], as well as a significant effect of dB on the startle intensity by genotype interaction [F (2,34) = 19.364, p < 0.001]. N = 9–10 mice/genotype; *p < 0.05, KO versus WT controls; † p < 0.05, compared with the 100 dB response; ‡ p < 0.05, compared with the 105 dB response