. Author manuscript; available in PMC: 2022 Sep 6.

Published in final edited form as: Mult Scler Relat Disord. 2022 Jun 24;65:103994. doi: 10.1016/j.msard.2022.103994

Table 2.

Covariate-adjusted regression analysis using area deprivation index in 2015 as the exposure and the median scores of patient-reported outcomes of neurological and physical function from the latest year between 2018 and 2020.

	Discovery Cohorts				Replication Cohorts
	Estimate ¹	95% CI ²	P-Value ³	N ⁴	Estimate ¹	95% CI ²	P-Value ³	N ⁴
MSRS-R	0.62	0.36, 0.89	<0.001	1248	0.46	0.21, 0.72	<0.001	421
PDDS	0.11	0.02, 0.20	0.020	1234	0.12	0.03, 0.21	0.009	416
PROMIS	−0.49	−1.08, 0.10	0.106	645	−0.60	−1.12, −0.08	0.025	378

^1.

Beta-coefficient from regression analysis adjusting for covariates as described in the Methods.

^2.

95% confidence intervals

^3.

The threshold for significance for each covariate-adjusted regression model with three separate outcomes was p=0.0167 after correction for multiple testing (in either discovery cohorts or in replication cohorts).

^4.

N, the number of observations for each covariate-adjusted regression model.