. Author manuscript; available in PMC: 2022 Sep 6.

Published in final edited form as: Mult Scler Relat Disord. 2022 Jun 24;65:103994. doi: 10.1016/j.msard.2022.103994

Table 3.

Covariate-adjusted regression analysis of individual driving components of the area deprivation index (ADI) in 2015 as the exposure and median scores of patient-reported outcomes of neurological function from the latest year between 2018 and 2020 from the joint cohorts.

		Estimate¹	95% CI²	P-Value³	N⁴
Neighborhood Median Household Income	MSRS-R	−3.80e-05	−5.05e-05, −2.56e-05	<0.001	1665
	PDDS	−8.58e-06	−1.28e-05, −4.32e-06	<0.001	1646
	PROMIS	2.55e-05	5.96e-07, 5.05e-05	0.044	1020
Neighborhood Median Home Value	MSRS-R	−6.50e-06	−8.16e-06, −4.84e-06	<0.001	1666
	PDDS	−1.54e-06	−2.11e-06, −9.65e-07	<0.001	1647
	PROMIS	4.98e-06	1.81e-06, 8.14e-06	0.00209	1021
Neighborhood Percent with College Education	MSRS-R	−7.31	−8.99, −5.64	<0.001	1668
	PDDS	−1.62	−2.20, −1.05	<0.001	1649
	PROMIS	9.31	5.73, 12.89	<0.001	1022

^1.

Beta-coefficient from regression analysis adjusting for covariates as described in the Methods.

^2.

95% confidence intervals

^3.

For each ADI component, the threshold for significance for each covariate-adjusted regression model with three separate outcomes was p=0.0167 after correction for multiple testing.

^4.

N, the number of observations for each covariate-adjusted regression model.