Table 1.
Echocardiographic parameters in wild-type (WT) and Arrdc4 knock-out (KO) mice 7 days after sham or MI surgeries.
| Sham | MI | P-value | |||||
|---|---|---|---|---|---|---|---|
| WT | Arrdc4-KO | WT | Arrdc4-KO | Sham WT vs. MI WT | Sham Arrdc4-KO vs. MI Arrdc4-KO | MI WT vs. MI Arrdc4-KO | |
| Echocardiography, n | 12 | 12 | 30 | 30 | |||
| Heart rate, beat/min | 750 (720–750) | 720 (720–750) | 720 (720–750) | 720 (720–750) | N.S. | N.S. | N.S. |
| End-diastolic dimension, mm | 2.9±0.1 | 2.8±0.1 | 4.5±0.1 | 4.0±0.1 | 1.5×10−11 | 9.0×10−7 | 4.1×10−3 |
| End-systolic dimension, mm | 0.9±0.1 | 0.9±0.1 | 3.5±0.2 | 2.8±0.1 | 1.0×10−15 | 1.2×10−13 | 1.9×10−4 |
| End-diastolic volume, μL | 31.6 ±2.0 | 30.6±2.3 | 90.8 (66.4–118.2) | 65.6 (50.3–89.0) | 1.3×10−7 | 1.3×10−4 | *5.0×10−3 |
| End-systolic volume, μL | 1.3 (0.8–2.7) | 1.5±0.7 | 50.9 (31.1–64.9) | 28.3 (19.3–41.1) | 1.5×10−8 | 2.1×10−4 | *4.4×10−3 |
| Anterior wall thickness, mm | 0.65±0.02 | 0.69±0.02 | 0.37 (0.36–0.39) | 0.39 (0.36–0.43) | 8.7×10−7 | 1.6×10−5 | N.S. |
| Posterior wall thickness, mm | 0.64±0.02 | 0.68 (0.64–0.71) | 0.64 (0.57–0.71) | 0.64 (0.60–0.68) | N.S. | N.S. | N.S. |
| Fractional shortening, % | 69±2 | 69±1 | 23±1 | 30±1 | 1.0×10−15 | 1.0×10−15 | 1.0×10−4 |
| LV mass / body weight, mg/g | 2.2±0.1 | 2.3±0.1 | 3.6±0.2 | 2.8 (2.3–3.2) | 1.9×10−5 | *4.4×10−3 | 4.7×10−2 |
LV mass, Left ventricular mass. The normally distributed data are expressed as mean ± SEM (two-way ANOVA post-hoc Bonferroni test), while not normally distributed data are expressed as median and quartiles (Kruskal-Wallis test followed by post-hoc Dunn’s test or *Mann-Whitney U test).