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. 2022 Sep 5;13:5226. doi: 10.1038/s41467-022-32597-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Isotherm plot of Wzt-CBM against 3-O-methyl-d-mannose (blue) and d-mannose (green) Raw data is provided as Source Data. b Overall structure of the Wzt-CBD dimer. Two monomers are colored separately as yellow and vanilla. 3-O-methyl-d-mannose is shown as green sticks. N- and C-terminal ends are shown in blue and red spheres, respectively. c Modeled 3-O-methyl-d-mannose into an unbiased F_OF_C map. Oxygen atoms are labeled by atom number. Mesh map was contoured at 3σ. d Surface representation of key residues that form the cap sugar-binding pocket. e Two orientations of key interactions between 3-O-methyl-d-mannose and Wzt-CBM. Trap loop and Trp362 from apo Wzt-CBM (PDB ID: 6O14) are colored in violet. The cap-induced movement of the trap loop and Trp362 is indicated with an arrow. Water is represented as a light blue sphere. Hydrogen bonds are shown as dashed lines colored in teal.