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. 2022 Sep 5;13:5226. doi: 10.1038/s41467-022-32597-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overview of the WzmWzt structure. Loops connecting the NBD with the CBD are colored red. The boxed region is enlarged in panel c. TMD: Transmembrane domain. b CBD position in the transporter’s ADP and ATP-bound conformations. The ATP-bound conformation is shown as a semi-transparent surface. The panel presents interactions between the NBD1 and CBD (ADP-bound). c The LG loop moves away from the channel entrance upon NBD opening. The cyan cartoon represents the previously reported IF-TM1 connection observed in the ATP-bound WzmWzt (PDB ID: 7K2T). The TM channel is shown as a gray surface (calculated in HOLLOW³⁵) and aromatic belt residues are shown as sticks.