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. 2022 Sep 5;13:5217. doi: 10.1038/s41467-022-32898-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Lhx6- (a) and Sst-expressing (b) MGE-derived cortical interneurons migrating into the developing neocortex at E13.5 in control (Ctrl), Mtg8^−/− and Mtg16^−/− embryos. c Scheme showing how Lhx6 and Sst quantification was performed for the data shown in Fig. 2d, e. A rectangle stretching from the cortico-striatal boundary to the tip of the developing neocortex was used to define the area of counting. Migrating interneurons in the MZ and SVZ/IZ as well as total numbers were quantified. The same rectangle was used for all embryos examined in order to allow comparison between control and mutants. d–g Quantification of cells in the neocortical MZ and the SVZ/VZ, as well as total cell numbers at E13.5 (d, e) and E18.5 (f, g). Reduced numbers of migrating Sst-expressing cells in Mtg8 mutant embryos. E13.5: n = 6 Ctrl, n = 3 mutant embryos. E18.5: n = 4 embryos for each genotype. One-way analysis of variance (ANOVA) followed by Uncorrected Fisher’s LSD tests. E13.5 Sst Mtg8^−/−: MZ P = 0.0083, SVZ/IZ P < 0.0001, Total P = 0.0002. E18.5 Sst Mtg8^−/−: Total P < 0.0001. **P < 0.01, ***P < 0.001, ****P < 0.0001. All graphs show mean ± SEM. Source data are provided as a Source Data file. Scale bar: 400 μm.