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. 2022 Sep 5;13:5217. doi: 10.1038/s41467-022-32898-6

Fig. 3. An autonomous requirement for MTG8 for embryonic specification of SST interneuron subsets.

Fig. 3

a Experimental design for in vivo transplantation of MGE precursors from control and mutant embryos at E13.5 into the cortex of newborn pups. b Quantification of surviving transplanted cells within the somatosensory cortex 40 days post transplantation. n = 8 brains for each genotype. Two-tailed Mann–Whitney U test. ***P < 0.001. c, d Immunohistochemistry for SST (c) or PV (d) and tdTOM/YFP to detect transplanted control and mutant MGE precursors differentiating into SST or PV interneurons and quantification. n = 4 brains per genotype. Two-way ANOVA followed by Uncorrected Fisher’s LSD tests. *P = 0.0307, ***P < 0.001. All graphs show mean ± SEM. Source data are provided as a Source Data file. Scale bars: (c, d) 100 μm and higher magnification 50 μm.