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. 2022 Sep 5;13:5217. doi: 10.1038/s41467-022-32898-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Domain structure of LHX6 and the truncated LHX6 protein used in this study, LHX6ΔLIM1/2, which lacks both LIM domains. Immunoprecipitation of WT or truncated LHX6 results in co-IP of MTG8 in transient transfection assays in Cos cells. Uncropped blots are provided as a Source Data file. b Domain structure of LDB1 and the truncated LDB1 protein used in this study, LDB1ΔLID, which lacks the LIM-interaction domain. Immunoprecipitation of WT or truncated LDB1 does not result in co-IP of MTG8 in transient transfection assays in Cos cells. Uncropped blots are provided as a Source Data file. c Experimental scheme for ectopic expression of LHX6-GFP, or MTG8-tdTOM, or both, in the embryonic cortex via whole head electroporation at E14.5-E15.5, followed by slice culture of coronal sections from electroporated brains. d Expression of Sst, and Npy in the developing neocortex upon ectopic expression of MTG8 and/or LHX6. Npy is upregulated only in the presence of both, MTG8 and LHX6 (arrows). Scale bar 400 μm.