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. 2022 Sep 5;5:912. doi: 10.1038/s42003-022-03889-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Changes in body weight after treatment. Sham-operated male, sham-operated female, and ovariectomised (OVX) female rats at 10 weeks of age. Tube implantation [oil-only, low E2 (20 μg β-oestradiol/ml sesame oil), and high E2 (400 μg β-oestradiol/ml sesame oil)] was performed in OVX female rats at 14 weeks of age. The data are presented as the mean ± SEM (repeated-measures ANOVA) (^**P < 0.01, compared with the treated rats; ^††P < 0.01, compared with all female rats). b Micro-CT imaging (9 weeks of age) of visceral fat (green), subcutaneous fat (yellow), and internal organs (red) in male and female rats are shown. Scale bar indicates 1 cm. c Ratio of visceral and subcutaneous fat to that within internal organs in male and female rats are shown. The data are presented as the mean ± SEM (one-way ANOVA) (*P < 0.05, compared with visceral fat of male rats). d Cumulative food intake for one day at 9 weeks of age. The data are presented as the mean ± SEM (t-test) (^**P < 0.01, compared with male rats). e Micro-CT imaging (14 weeks of age) of visceral fat (green), subcutaneous fat (yellow), and internal organs (red) in sham-operated male, sham-operated female, and OVX female rats are shown. Scale bar indicates 1 cm. f Ratio of visceral and subcutaneous fat to that within internal organs in sham-operated male, sham-operated female, and OVX female rats are shown. The data are presented as the mean ± SEM (one-way ANOVA) (^*P < 0.05, compared with sham-operated female rats). g Cumulative food intake for one day at 14 weeks of age. The data are presented as the mean ± SEM (one-way ANOVA) (^**P < 0.01, compared with sham-operated male rats). h Micro-CT imaging (16 weeks of age) of visceral fat (green), subcutaneous fat (yellow), and internal organs (red) in OVX + oil-only, OVX + low E2, and OVX + high E2 female rats are shown. Scale bar indicates 1 cm. i Ratio of visceral and subcutaneous fat to that within internal organs in OVX + oil-only, OVX + low E2, and OVX + high E2 female rats are shown. The data are presented as the mean ± SEM (one-way ANOVA) (^*P < 0.05, compared with OVX + oil-only female rats). j Cumulative food intake for one day at 16 weeks of age. The data are presented as the mean ± SEM (one-way ANOVA) (^**P < 0.01, compared with OVX + oil-only female rats).