Table 2.
Main results.
| Analysis | Odds ratio | Heterogeneity | Prediction Interval | Egger’s Test |
|---|---|---|---|---|
| Primary Outcome |
1.67 [1.49–1.87], p < 0.001, N = 15 |
I² = 6.4%, τ = 0.058 | 1.40–1.99 | p = 0.964 |
| Low RoB |
1.66 [1.40–1.97], p < 0.001, N = 5 |
I² = 41.6%, τ = 0.114 | 1.05–2.62 | |
| Overt |
1.70 [1.49–1.93], p < 0.001, N = 8 |
I² = 12.9%, τ = 0.069 | 1.34–2.14 | |
| Subclinical |
1.36 [1.06–1.74], p = 0.015, N = 11 |
I² = 13.4%, τ = 0.151 | 0.87–2.12 | p = 0.262 |
| Female |
1.37 [0.91–2.05], p = 0.130, N = 3 |
I² = 46.7%, τ = 0.254 | 0.02–87.42 | |
| Male |
1.84 [1.34–2.54], p < 0.001, N = 3 |
I² = 0%, τ = 0.000 | 0.23–14.81 | |
| Post-hoc | ||||
| Hypothyroidism |
1.36 [1.02–1.82], p = 0.037, N = 14 |
I² = 63.8%, τ = 0.373 | 0.57–3.27 | p = 0.711 |
| Hyperthyroidism |
1.61 [1.34–1.93], p < 0.001, N = 14 |
I² = 13.0%, τ = 0.124 | 1.14–2.25 | p = 0.973 |
Effects are reported as OR and 95% confidence interval. N describes the number of studies included in the analysis. Egger's p-value is reported as two-sided, values <0.1 indicate potential publication bias. For reasons of power, Egger’s test was only carried out if at least 10 studies were included in the analysis.
Additional results can be obtained from the supplementary information.