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. 2022 Aug 23;10:893059. doi: 10.3389/fped.2022.893059

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Copyright © 2022 Casaburi, Wei, Kazi, Liu, Wang, Tao, Lin, Dunn, Henrick, Frese and Sylvester.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Formate causes intestinal epithelial injury in vivo. (A) Luminal administration of formate induces intestinal epithelial injury of neonatal mice in an age-dependent manner as 14-day mice and 28-day mice demonstrate a differential response to the same challenge (n = 8 in each group; Paired t-test was performed). (B) H&E stain of mouse intestines that were treated with or without 150 mM of Formate (V, villus; E, epithelial cells; M, muscle layer; L, lumen; C, crypt). (B) Histological grading scale of mouse intestinal epithelium; [unpaired t-test). Ctrl, control]. (C) Histological grading scale of mouse intestinal epithelium; (unpaired t-test) Ctrl, control.