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. 2022 Aug 23;10:893059. doi: 10.3389/fped.2022.893059

Table 1.

Formic acid uniquely elevated in fecal samples of human newborns with NEC.

Healthy control NEC on-set NEC recovery p p
(μmole/gram of stool) Mean SD Mean SD Mean SD NEC on-set vs. control NEC on-set vs. recovery
Glycolic acid 1.542 0.464 1.370 0.128 2.704 2.124 0.287 0.185
Lactic acid 4.835 6.366 2.712 2.275 5.525 11.224 0.347 0.570
Formic acid 0.651 0.900 4.399 3.518 0.608 0.559 0.020** 0.019**
Acetic acid 7.917 3.491 9.413 3.463 9.003 1.975 0.378 0.785
Propionic acid 0.688 0.509 0.964 0.868 1.036 1.356 0.442 0.913
Isobutyric Acid 0.070 0.133 0.001 0.001 0.161 0.190 0.135 0.094
Butyric acid 0.204 0.132 2.089 5.494 0.570 0.765 0.364 0.464
Succinic acid 5.691 10.453 4.273 3.055 4.709 4.821 0.691 0.851
Valeric acid 0.105 0.127 0.136 0.242 0.037 0.010 0.746 0.286
indole-3-lactic acid 0.018 0.058 0.000 0.000 0.000 0.000 0.343 na
indole-3-acetic acid 0.055 0.054 0.019 0.003 0.032 0.025 0.066 0.249
indole-3-propionic acid 0.149 0.057 0.113 0.003 0.115 0.004 0.073 0.307
Hexanoic acid 0.353 0.100 1.160 1.939 0.344 0.064 0.277 0.273
indole-3-butyric acid 0.256 0.026 0.239 0.001 0.240 0.002 0.075 0.273
Pyruvic acid 0.771 0.393 0.714 0.564 0.608 0.311 0.815 0.660
**

p < 0.05, statistic significance.