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. 2022 Aug 23;12:974200. doi: 10.3389/fcimb.2022.974200

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Copyright © 2022 Grajeda, De Chatterjee, Villalobos, Pence, Ellis, Enriquez, Roy, Roychowdhury, Neumann, Almeida, Patterson and Das

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteomic comparison of rafts, LVs and SVs. (A) Venn diagram showing the distribution of proteins in three different components. (B) Volcano plots showing differentially expressed proteins between control and treatments with nystatin (27 μM) and oseltamivir (20 μM). Comparisons are shown in graphs a’ (raft control vs nystatin); b’ (raft control vs oseltamivir); c’ (LVs control vs nystatin), d’ (LVs control vs oseltamivir); e’ (SVs control vs nystatin) and f’ (SVs control vs oseltamivir). Volcano plots show –log10 P-values from the normalized proteomics data exported from Scaffold LFQ vs. log2 foldchange (FC) across each contrast (A–F). Thresholds set were p-value ≤.05 and Log2FC ≤ -1.5 or ≥ 1.5.