TABLE 1.
The expression and roles of circSMARCA5 in various cancers.
| Tumor types | Samples | Expression | Mechanism | Functional roles | Ref |
|---|---|---|---|---|---|
| GC | 23 pairs | down | miR-346/FBXL2 | suppress proliferation, migration and invasion | Li and Hu (2019) |
| 60 pairs | down | — | inhibit proliferation, migration, and invasion | Cai and Zuo, (2019) | |
| GBM | 56 tumor 7 normal |
down | SRSF1/SRSF3/PTBP1/PTBP2 | inhibit migration and angiogenesis | Barbagallo et al. (2018) |
| HCC | 133 pairs | down | — | inhibit proliferation, invasion and metastasis, promote late apoptosis | Li and Hu (2019) |
| 73 pairs | down | — | suppress proliferation, migration and invasion, enhance apoptosis | Zhang and Xiao, (2018) | |
| 40 pairs | down | DHX9/circSMARCA5/miR-17-3p/miR-181b-5p/TIMP3 | suppress growth, migration and distant metastasis | Yu et al. (2018) | |
| NSCLC | 66 pairs | down | miR-670-5p/RBM24 | suppress growth | Zhang et al. (2020) |
| 460 pairs | down | — | inhibit proliferation and strengthen hemotherapy sensitivity | Tong, (2020) | |
| ICC | 92 pairs | down | — | inhibit proliferation and increase chemotherapy sensitivity | Lu, (2020) |
| MM | 105 tumor, 36 normal | down | miR-767-5p | inhibit proliferation and promote apoptosis | Liu et al. (2019) |
| CRC | 35 pairs | down | miR-552/Wnt /YAP1 |
suppress proliferation, migration, invasion and promote apoptosis | Yang G et al. (2021) |
| 45 pairs | down | miR-39-3p/ARID4B | inhibit proliferation, migration and invasion | Miao et al. (2020) | |
| CC | 30 pairs | down | miR-620 | inhibit proliferation, migration and invasion | Tian, (2018) |
| 20 pairs | down | SND1/YWHAB | suppress proliferation and invasion, enhance apoptosis | Zhang Z et al. (2021) | |
| BC | — | down | SMARCA5 | suppress DNA repair capacity and improve chemotherapy sensitivity | Xu et al. (2020) |
| PCa | 30 pairs | up | miR-432/PDCD10 | promote proliferation, metastasis, and glycolysis | Dong et al. (2021) |
| 21 pairs | up | — | promote proliferation, inhibit apoptosis and affect cell cycle | Kong et al. (2017) | |
| BCa | 156 tumor 71 normal | up | — | promotes proliferation, migration, invasion and inhibit apoptosis | Tan and Liang. (2019) |
Abbreviations: GC: gastric cancer; GBM: glioblastoma; HCC: hepatocellular carcinoma; NSCLC: non-small -cell lung cancer; ICC: intrahepatic cholangiocarcinoma; MM: multiple myeloma; CRC: colorectal cancer; CC: cervical cancer; BC: breast cancer; PCa: prostate cancer; BCa: bladder cancer.