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. 2022 Aug 23;13:919032. doi: 10.3389/fphar.2022.919032

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Copyright © 2022 Yang, Li, Cheng, Lu, Li, Feng, Wang and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dex increases urine output and decreases plasma osmolality. (A) The experimental protocol for urine and blood collection after saline, Dex or AVP administration. (B) Urine volume of each group within 6 h after injection of saline or Dex (n = 8 in the Saline, 50 μg/kg Dex and 200 μg/kg Dex group, n = 16 in the 100 μg/kg Dex group, n = 9 in the 100 μg/kg Dex-3 µg/kg AVP group). (C) Plasma osmolality of mice in each group 6 h after injection of saline or Dex (n = 8 in all groups). *p < 0.05 and **p < 0.01 indicate significant differences among the saline and Dex groups assessed using one-way ANOVA.