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. 2022 Aug 23;12:941347. doi: 10.3389/fonc.2022.941347

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Copyright © 2022 Ma, Ma, Ma, Liu, Gu, Liu, Xiang, Liu and Sang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNA-based targeted sequencing revealed the genetic disparity between CD5+ and CD5- DLBCL. The most enriched gene variations in (A) CD5+ DLBCL and (B) CD5- DLBCL showed remarkable differences. The composition of genetic variation types of (C) CD5+ DLBCL and (D) CD5- DLBCL. (E) Mutations with available inhibitors were more frequently shown in CD5+ DLBCL. (F, G) CD5+ DLBCL showed elevated CIN but similar TMB compared with CD5- DLBCL. SV, structural variation; CNV, copy number variation; CIN, chromosomal instability; TMB, tumor mutational burden; NS, not significant.