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. 2022 Aug 23;9:791143. doi: 10.3389/fcvm.2022.791143

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Copyright © 2022 Wang, Abe, Chau, Wang, Vu, Reddy Velatooru, Gulraiz, Imanishi, Samanthapudi, Nguyen, Ko, Lee, Thomas, Olmsted-Davis, Kotla, Fujiwara, Cooke, Zhao, Evans and Le.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential gene expression profiles between siMAGI1 vs. siCont-treated ECs. (A) Statistical significance of the IPA-determined biological function and disease gene enrichment in siMAGI1-treated ECs calculated by the right-tailed Fisher exact test and presented as –log(P) value. A larger value on the y-axis represents greater significance. A total of 252 genes were differentially expressed in siMAGI1-transfected ECs compared to that in siCont-transfected ECs (P < 0.05; absolute fold change >2). The p-value, calculated by the Fischer's exact test, reflects the likelihood that the association among a set of genes in the data set and a related biological function is significant. (B) Graphical summary of IPA results showing significant predictor genes that are related to antiviral response.