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. 2022 Aug 23;12:918719. doi: 10.3389/fonc.2022.918719

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Copyright © 2022 Wang, Zhang, Li, Yu, Chen, Liu, Zhang and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis between FN1 and related genes and markers of macrophages. (A) FN1 expression is negatively related to tumor purity and has significant positive correlations with infiltrating levels of Tregs, CD4+ T cells, CD8+ T cells, and macrophages in STAD. (B–D) Scatterplots of correlations between FN1 expression and gene markers of macrophages, TAMs (B), and M1 (C) and M2 macrophages (D) in STAD. (E) Correlation between FN1 expression and Macrophage in gastric cancer available at the TISIDB database. Color images are available online (n = 415). (F) Correlation between FN1 expression and CD163 in gastric cancer. Gastric cancer tissue was quantitated by scoring staining intensity, including negative (–) and weak (+) staining, moderate (++) and strong (+ + +) staining, respectively. Scale bar = 100 μm. (G) OS and DFS analysis of FN1 in STAD.