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. 2022 Aug 23;10:948812. doi: 10.3389/fcell.2022.948812

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Copyright © 2022 Phothichailert, Nowwarote, Fournier, Trachoo, Roytrakul, Namangkalakul and Osathanon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Jagged1 promotes mineralization and ECM gene expression in hDPSCs. Human dental pulp stem cells (hDPSCs) were characterized by flow cytometry to examine surface protein marker expression (A). Mineralization was examined using Alizarin Red S staining on day 14 after osteogenic induction (B–C). Intracellular lipid accumulation was detected using Oil Red O staining on day 16 after adipogenic induction (D–E). The effect of Jagged1 on hDPSCs was examined. Bioinformatic analysis of RNA sequencing data of genes related to ECM organization was illustrated by heatmap (F). Morphology, mineralization, and alkaline phosphatase enzymatic activity (ALP) were examined (G).