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. 2022 Aug 23;13:962525. doi: 10.3389/fphar.2022.962525

TABLE 4.

Quinones with anti-hepatic fibrosis effect.

No. Compounds Source Molecular formula Mechanisms Refs
37 Emodin Rheum palmatum L. C15H10O5 Inhibiting HSC activation by mediating TGF-β/Smads signaling pathway Dong et al. (2009), Feng Liu et al. (2018)
38 Rhein Rheum palmatum L. C15H8O6 Antioxidant and anti-inflammatory responses. Guo et al. (2002)
39 Sparstolonin B Sparganium stoloniferum (Graebn.), Buch-Ham. ex Juz. C15H8O5 Inhibiting TLR4 signaling transduction pathway Dattaroy et al. (2018)
40 Tanshinone IIA Salvia miltiorrhiza Bge. C19H18O3 Inhibiting HSC activation and proliferation Liu and Huang, (2014), Stanković et al. (2017)