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. 2022 Aug 23;13:962525. doi: 10.3389/fphar.2022.962525

TABLE 7.

Phenylpropanoids with anti-hepatic fibrosis effect.

No. Compounds Source Molecular formula Mechanisms Refs
58 Curcumin Curcuma longa L. C21H20O6 Regulating oxidative stress and autophagy, passivation of hepatocyte epithelial-mesenchymal transformation Kong et al. (2020)
59 Isochlorogenic acid A Lonicera japonica Thunb. C25H24O12 Inhibiting HMGB1/TLR4/NF-κB signaling pathways Liu et al. (2020)
60 Phillygenin Forsythia suspensa (Thunb.) Vahl C21H24O6 Regulating TLR4/MyD88/NF-κB signaling pathways Hu et al. (2020b)
61 Salvianolic acid B Salvia miltiorrhiza Bge. C36H30O16 Inhibiting HSC proliferation and collagen synthesis, Decreasing TGF-β1 autocrine and MAPK activity Liu et al. (2002)
62 Schizandrin B Schisandra chinensis (turcz.) baill. C23H28O6 Regulating Nrf2-ARE and TGF-β/Smad signaling pathways Chen et al. (2017)