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. 2022 Aug 23;13:955566. doi: 10.3389/fphys.2022.955566

TABLE 4.

Effect of channel flicker on voltage threshold.

Ramp peak (nA) First spike Vth (mV) Mean Vth (mV)
NaT CaL NaP K(DR) NaT CaL NaP K(DR)
0.2 Control −47.3 ± 0.8 −46.5 ± 4.6
Control + CF −48.9 ± 1.0 −47.6 ± 0.9 −48.2 ± 1.0 −48.9 ± 0.5 −47.8 ± 3.3 −46.2 ± 3.8 −47.2 ± 3.6 −46.9 ± 3.0
WN −47.6 ± 0.7 −47.4 ± 4.3
WN + CF −49.6 ± 1.8 −49.1 ± 1.4 −48.3 ± 0.7 −49.2 ± 0.8 −47.6 ± 2.5 −45.9 ± 3.3 −45.9 ± 4.3 −47.0 ± 3.6
0.4 Control −46.6 ± 1.0 −48.3 ± 4.2
Control + CF −48.5 ± 0.7 −47.2 ± 1.4 −47.7 ± 1.7 −49.1 ± 0.5 −48.7 ± 2.3 −47.6 ± 3.2 −46.7 ± 2.8 −47.1 ± 2.9
WN −48.2 ± 1.1 −48.6 ± 5.1
WN + CF −50.1 ± 1.6 −49.0 ± 1.1 −49.4 ± 1.4 −48.6 ± 1.1 −48.5 ± 2.6 −48.1 ± 2.9 −45.0 ± 3.7 −46.5 ± 3.3
0.6 Control −45.9 ± 1.0 −45.5 ± 4.6
Control + CF −48.9 ± 1.0 −47.6 ± 0.9 −47.0 ± 1.1 −48.2 ± 1.1 −47.0 ± 2.8 −46.4 ± 4.1 −46.0 ± 3.5 −46.8 ± 3.3
WN −47.8 ± 1.0 −47.7 ± 3.8
WN + CF −49.4 ± 1.8 −49.2 ± 1.5 −48.3 ± 0.9 −49.2 ± 0.7 −45.5 ± 3.5 −46.7 ± 3.6 −45.5 ± 4.0 −46.3 ± 3.0
0.8 Control −46.3 ± 1.8 −45.9 ± 2.9
Control + CF −49.1 ± 1.0 −47.5 ± 0.9 −48.1 ± 1.5 −49.0 ± 0.9 −47.1 ± 2.9 −46.2 ± 3.4 −45.9 ± 2.7 −47.2 ± 2.8
WN −48.9 ± 0.8 −47.3 ± 3.6
WN + CF −50.5 ± 1.0 −49.5 ± 1.1 −49.6 ± 1.4 −49.9 ± 1.5 −46.5 ± 3.3 −46.6 ± 4.3 −45.8 ± 3.3 −46.1 ± 3.6
1.0 Control −46.4 ± 1.3 −46.1 ± 3.5
Control + CF −48.6 ± 1.1 −47.5 ± 1.5 −47.3 ± 1.5 −49.4 ± 0.9 −47.4 ± 3.1 −47.6 ± 4.2 −47.3 ± 3.0 −46.8 ± 3.3
WN −48.9 ± 1.1 −46.6 ± 3.3
WN + CF −51.4 ± 1.5 −50.0 ± 1.1 −50.0 ± 0.9 −50.3 ± 1.2 −47.5 ± 2.6 −48.0 ± 3.5 −45.6 ± 3.5 −47.0 ± 4.3
1.2 Control −46.1 ± 1.0 −48.3 ± 3.1
Control + CF −48.3 ± 0.8 −47.3 ± 1.3 −47.7 ± 1.4 −49.3 ± 0.8 −48.3 ± 3.1 −46.4 ± 3.1 −46.1 ± 3.3 −46.9 ± 2.9
WN −48.6 ± 1.0 −46.6 ± 3.9
WN + CF −52.2 ± 1.7 −50.5 ± 0.7 −50.6 ± 1.3 −50.0 ± 1.3 −46.3 ± 2.3 −46.5 ± 4.2 −46.7 ± 3.9 −45.6 ± 4.2