TABLE 4.
Effect of channel flicker on voltage threshold.
| Ramp peak (nA) | First spike Vth (mV) | Mean Vth (mV) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| NaT | CaL | NaP | K(DR) | NaT | CaL | NaP | K(DR) | ||
| 0.2 | Control | −47.3 ± 0.8 | −46.5 ± 4.6 | ||||||
| Control + CF | −48.9 ± 1.0 | −47.6 ± 0.9 | −48.2 ± 1.0 | −48.9 ± 0.5 | −47.8 ± 3.3 | −46.2 ± 3.8 | −47.2 ± 3.6 | −46.9 ± 3.0 | |
| WN | −47.6 ± 0.7 | −47.4 ± 4.3 | |||||||
| WN + CF | −49.6 ± 1.8 | −49.1 ± 1.4 | −48.3 ± 0.7 | −49.2 ± 0.8 | −47.6 ± 2.5 | −45.9 ± 3.3 | −45.9 ± 4.3 | −47.0 ± 3.6 | |
| 0.4 | Control | −46.6 ± 1.0 | −48.3 ± 4.2 | ||||||
| Control + CF | −48.5 ± 0.7 | −47.2 ± 1.4 | −47.7 ± 1.7 | −49.1 ± 0.5 | −48.7 ± 2.3 | −47.6 ± 3.2 | −46.7 ± 2.8 | −47.1 ± 2.9 | |
| WN | −48.2 ± 1.1 | −48.6 ± 5.1 | |||||||
| WN + CF | −50.1 ± 1.6 | −49.0 ± 1.1 | −49.4 ± 1.4 | −48.6 ± 1.1 | −48.5 ± 2.6 | −48.1 ± 2.9 | −45.0 ± 3.7 | −46.5 ± 3.3 | |
| 0.6 | Control | −45.9 ± 1.0 | −45.5 ± 4.6 | ||||||
| Control + CF | −48.9 ± 1.0 | −47.6 ± 0.9 | −47.0 ± 1.1 | −48.2 ± 1.1 | −47.0 ± 2.8 | −46.4 ± 4.1 | −46.0 ± 3.5 | −46.8 ± 3.3 | |
| WN | −47.8 ± 1.0 | −47.7 ± 3.8 | |||||||
| WN + CF | −49.4 ± 1.8 | −49.2 ± 1.5 | −48.3 ± 0.9 | −49.2 ± 0.7 | −45.5 ± 3.5 | −46.7 ± 3.6 | −45.5 ± 4.0 | −46.3 ± 3.0 | |
| 0.8 | Control | −46.3 ± 1.8 | −45.9 ± 2.9 | ||||||
| Control + CF | −49.1 ± 1.0 | −47.5 ± 0.9 | −48.1 ± 1.5 | −49.0 ± 0.9 | −47.1 ± 2.9 | −46.2 ± 3.4 | −45.9 ± 2.7 | −47.2 ± 2.8 | |
| WN | −48.9 ± 0.8 | −47.3 ± 3.6 | |||||||
| WN + CF | −50.5 ± 1.0 | −49.5 ± 1.1 | −49.6 ± 1.4 | −49.9 ± 1.5 | −46.5 ± 3.3 | −46.6 ± 4.3 | −45.8 ± 3.3 | −46.1 ± 3.6 | |
| 1.0 | Control | −46.4 ± 1.3 | −46.1 ± 3.5 | ||||||
| Control + CF | −48.6 ± 1.1 | −47.5 ± 1.5 | −47.3 ± 1.5 | −49.4 ± 0.9 | −47.4 ± 3.1 | −47.6 ± 4.2 | −47.3 ± 3.0 | −46.8 ± 3.3 | |
| WN | −48.9 ± 1.1 | −46.6 ± 3.3 | |||||||
| WN + CF | −51.4 ± 1.5 | −50.0 ± 1.1 | −50.0 ± 0.9 | −50.3 ± 1.2 | −47.5 ± 2.6 | −48.0 ± 3.5 | −45.6 ± 3.5 | −47.0 ± 4.3 | |
| 1.2 | Control | −46.1 ± 1.0 | −48.3 ± 3.1 | ||||||
| Control + CF | −48.3 ± 0.8 | −47.3 ± 1.3 | −47.7 ± 1.4 | −49.3 ± 0.8 | −48.3 ± 3.1 | −46.4 ± 3.1 | −46.1 ± 3.3 | −46.9 ± 2.9 | |
| WN | −48.6 ± 1.0 | −46.6 ± 3.9 | |||||||
| WN + CF | −52.2 ± 1.7 | −50.5 ± 0.7 | −50.6 ± 1.3 | −50.0 ± 1.3 | −46.3 ± 2.3 | −46.5 ± 4.2 | −46.7 ± 3.9 | −45.6 ± 4.2 | |