| 1 Mental state: 1. Overall a. Not improved (total PANSS) |
1 |
83 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.70 [0.55, 0.88] |
| 2 Mental state: 1. Overall b. Average change score (PANSS, low=good) |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
‐26.33 [‐37.71, ‐14.95] |
| 3 Mental state: 1. Overall c. Average endpoint score (PANSS, low=good) |
3 |
176 |
Mean Difference (IV, Fixed, 95% CI) |
‐10.74 [‐15.39, ‐6.09] |
| 4 Mental state: 2. Negative symptoms a. Not improved (PANSS) |
1 |
83 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.72 [0.57, 0.90] |
| 5 Mental state: 2. Negative symptoms b. Average score at endpoint (PANSS, low=good) |
5 |
243 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.92 [‐3.06, ‐0.78] |
| 6 Mental state: 2. Negative symptoms c. Average score at endpoint (SANS, low=good) |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
4.80 [0.94, 8.66] |
| 7 Mental state: 2. Negative symptoms d. Average change score (PANSS, greater decrease=good) |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.0 [‐9.87, ‐2.13] |
| 8 Mental state: 3. Positive symptoms a. Not improved (PANSS) |
1 |
83 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.98 [0.79, 1.22] |
| 9 Mental state: 3. Positive symptoms b. Average score at endpoint (PANSS, low=good) |
5 |
243 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.46 [‐2.50, ‐0.42] |
| 10 Mental state: 3. Positive symptoms c. Average score at endpoint (SAPS, low=good) |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
2.80 [0.80, 4.80] |
| 11 Mental state: 3. Positive symptoms d. Average change score (PANSS, greater decrease=good) |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.27 [‐9.19, ‐1.35] |
| 12 Mental state: 4. Depresssive symptoms: a. Average score (CDS, greater decrease=good) |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.90 [‐4.86, ‐0.94] |
| 13 Mental state: 5. Resilience a. Average score at end‐point (Resilience scale, high=good) |
1 |
50 |
Mean Difference (IV, Fixed, 95% CI) |
3.20 [‐11.27, 17.67] |
| 14 Social functioning: 1. Overall a. Not improved (total SOFS) |
1 |
83 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.88 [0.77, 1.00] |
| 15 Social functioning: 1. Overall b. Average score at endpoint (SOFS, high score=good) |
2 |
76 |
Mean Difference (IV, Fixed, 95% CI) |
0.64 [‐2.12, 3.39] |
| 16 Social functioning 1. Overall c. Average score at endpoint (FACT‐Sz, high score=good) |
2 |
99 |
Mean Difference (IV, Fixed, 95% CI) |
4.26 [0.81, 7.71] |
| 17 Social functioning: 2. Emotional recognition ‐ average score (TRACS, high score=good) |
1 |
49 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.30 [‐10.07, 1.47] |
| 18 Adverse events |
1 |
188 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 18.1 any serious |
1 |
94 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 18.2 others |
1 |
94 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 19 Quality of life: 1. Average change (WHOQOL‐BREF, greater increase=good) |
1 |
72 |
Mean Difference (IV, Fixed, 95% CI) |
17.53 [8.64, 26.42] |
| 19.1 physical health |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
17.55 [3.10, 32.00] |
| 19.2 psychological |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
28.13 [9.01, 47.25] |
| 19.3 social relationships |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
14.47 [‐3.25, 32.19] |
| 19.4 environment |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
7.58 [‐15.08, 30.24] |
| 20 Quality of life: 2. Average change (SF‐36, greater increase=good) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
10.10 [3.06, 17.15] |
| 20.1 physical health |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
6.60 [‐2.44, 15.64] |
| 20.2 mental health |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
15.5 [4.27, 26.73] |
| 21 Quality of life: 3. Average end‐point index scale (EQ‐5D, high score=good) |
2 |
99 |
Mean Difference (IV, Fixed, 95% CI) |
0.05 [‐0.06, 0.16] |
| 22 Leaving the study early: people lost to follow up ‐ short term (low=good) |
8 |
457 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.91 [0.60, 1.37] |
