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. 2022 Feb 1;12(5):447–454. doi: 10.1016/j.jtcme.2022.01.006

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Fig. 3 — mRNA expression in hippocampus and cortex of mice. (A) Apoe/fas animals treated with resveratrol (n = 10) had significantly higher expression of SIRT1 in the hippocampus compared to apoe/fas animals treated with resveratrol and istradefylline (n = 9) but not compared to apoe/fas controls (n = 6) using a Welch's ANOVA test. (B) Apoe/fas animals treated with resveratrol (n = 10) had significantly lower expression of CX3CL1 in the hippocampus compared to apoe/fas animals treated with resveratrol and istradefylline (n = 9) but not compared to apoe/fas controls (n = 5) using a one-way ANOVA test. (C) Apoe/fas animals treated with resveratrol (n = 14) had significantly lower expression of VEGF in the hippocampus compared to apoe/fas and apoe/fas + resveratrol + istradefylline animals combined (n = 9) using a Welch's ANOVA test. (D) Apoe/fas animals treated with resveratrol (n = 14) showed a trend towards higher expression of F4/80 in the hippocampus compared to apoe/fas and apoe/fas + resveratrol + istradefylline animals combined (n = 10) using a Welch's ANOVA test. The data represent fold change with 95% CI. ∗-p<0.05; NS – not signficant. DKO = double knockout, DKOR = double knockout + resveratrol, DKORI = double knockout + resveratrol + istradefylline.