Table 4.

Summary of findings and Grade of Evidence Rating

Included studies			Quality assessment
First author	year	No. of studies/ subjects	Study design	Risk of bias	Imprecision	Inconsistency	Indirectness	Publication bias	Other considerations	Quality of evidence
SICPRE1	2018	45	non-systematic review	very seriousa,e	seriousb	very seriousk	seriousd	undetected	none	very low
SCOTTISH4	2008	218	systematic review	very seriousa,f,h	not serious	not serious	very seriousg	undetected	none	moderate
ISS8	2011	215	systematic review	very seriousa,h	not serious	not serious	very seriousg	likelyi	none	moderate
Vasconcelos13	2017	346	retrospective	very seriousj	very seriousl	seriousk	not serious	undetected	events distribution does not consent a proper statistical analysis	very low
Eberlin KR3	2015	20	non-systematic review	very seriousa,c	not serious	very seriousm	very seriousg	undetected	none	very low
Zapata- Copete J11	2017	5	meta-analysis	seriouse	very seriousl	not serious	not serious	undetected	none	moderate
Huang9	2015	12	meta-analysis	seriousc	not serious	very seriousm	not serious	undetected	none	low
Phillips10	2016	7	systematic review	seriousc	seriousb	very seriousk,m	seriousd	undetected	none	very low
Metcalfe14	2015	4	meta-analysis	seriousn,o	not serious	not serious	not serious	undetected	none	moderate
AICPE12	2015	/	narrative review	very seriousa,c,f	/	very seriousm	very seriousg	likely	absence of references does not consent critical analysis	very low
Robinson25	2019	22	experimental	very seriousn,o	very seriousl	not serious	seriousp	undetected	none	very low
Patel23	2012	1/16	case report / non-systematic review	very seriousa,c	seriousb	very seriousk,m	seriousg	undetected	none	very low
Herlin24	2016	41	systematic review	very seriousa,c	seriousb	very seriousk,m	very seriousg	undetected	none	very low
Yaffe15	2014	42	narrative review	very seriousa,c,f	very seriousb	very seriousk,m	very seriousg	likely	none	very low
Aryan5	2015	67	systematic review	very seriousa,f,q	seriousr	not serious	seriouss	undetected	none	moderate
NICE16	2019	3	systematic review	seriousf	seriousb	seriousk	not serious	undetected	none	moderate
Ramos17	2017	19	systematic review	very seriousc,e,j,n,o	seriousb	very seriousk,m	not serious	undetected	none	very low
Barajas-Nava18	2013	35	systematic review	seriousn,o	seriousb	seriousm	seriouss	undetected	none	low
Avni19	2010	17	meta-analysis	seriouse,o	seriousb,r	seriousm	seriousg,s	undetected	none	low
Chahed21	2014	80	prospective	very seriousa,c,n,t	not serious	very seriousk,m	seriousg	undetected	none	very low
Csenkey20	2019	6	meta-analysis	very seriousa,b,e	seriousb	seriousk	seriousg	likely	none	low