Figure 2.

Outcome of competitive fitness experiments of 12 longitudinal courses in murine (left) and human PCLS (right). Relative growth changes of serial P. aeruginosa isolates during competitive fitness experiments are compared at 4 h and 8 h, respectively. Severe longitudinal courses are labeled with red, mild courses with blue letters. Each serial isolate is differentiated by color sorted by increasing colonization time of the clone in the patient’s lungs: P. aeruginosa strains marked without a black outer ring were recovered at such low quantities that the strain-specific SNP counts were classified as ‘detectable, but not quantifiable’ (see Material and methods section). The axis labeling as well as the scaling and the color of the isolates are explained in more detail in Supplementary Dataset S1 showing all plots at higher resolution. Supplementary Figure S1 shows the outcome of the other biological replicate.