Table 2.
Prospective (observational) cohort studies evaluating rate of rupture of intracranial aneurysms across time.
| Study | Participants (n) | Women (%) | Proportion of patients not treated with aneurysm occlusion (%) | Population | Minimum and/or maximum aneurysm size (mm) | Mean/median aneurysm size (diameter, mm) | Rupture events | Patient-years |
|---|---|---|---|---|---|---|---|---|
| Wiebers et al. 24 a | 1692 | 75 | 42% (1692/4060) | European and North American | ≥2 b | 7.4 ± 6.9 | 51 | 6544 |
| Broderick et al. 23 | 113 | 66 | – | North American, Australian, Austra-Asian | ≥2 | NA c | 2 | 167 |
| Sonobe et al. 22 | 374 | 64 | 84% (374/446) | Japanese | <5 | 3.3 ± 0.9 | 7 | 1306 |
| Morita et al. 21 | 5720 | 68 | 63% (4195/6697) | Japanese | >3 | 5.7 ± 3.6 | 111 | 11,684 |
| Güresir et al. 20 | 263 | 78 | Germans | <7 | NA d | 3 | 1500 | |
| Ishibashi et al. 19 | 603 | 71 | – | Japanese | ≥2 | NA e | 19 | 1406 |
| Rinaldo et al. 16 | 214 | 66 | – | North American | 2–45 | NA f | 8 | 884 |
| Murayama et al. 18 | 1556 | 68 | 87% (1960/2252) | Japanese | >2 | 3.4 ± 2.2 | 56 | 7368 |
| Juvela et al. 17 | 142 | 54 | – | Finnish | 2–26 | 5.1 ± 3.7 | 34 | 3064 |
a
A small proportion of patients had an associated condition, such as arteriovenous malformation (2.0%) or polycystic kidney disease (1.6%).
b
85% of patients had aneurysms with size ≤12 mm.
c
Only five patients had an aneurysm ≥7 mm.
d
Mean diameter was 3.6 ± 1.7 mm in patients without aneurysm rupture during follow-up and 3 ± 1 mm in ruptured aneurysms.
e
74% of all aneurysms were small (<5 mm).
f
13.1% of all aneurysms within the size category of ≥10 mm.