Table 4.
GRADE table PICO 2.
| Question: Microsurgical compared to endovascular intervention and outcome | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Setting: UIA patients | ||||||||||||
| Certainty assessment | No. of patients | Effect | Certainty | Importance | ||||||||
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Neurosurgical | Endovascular intervention | Relative (95% CI) | Absolute (95% CI) | ||
| Poor outcome (mRS 3–6) | ||||||||||||
| 3 | Observational studies | Serious a | Not serious | Not serious | Serious c | None | 32/1997 (1.6%) | 8/528 (1.5%) | OR 1.45 (0.63–3.31) | Seven more per 1000 (from 6 fewer to 33 more) | ⨁◯◯◯ Very low | Critical |
| Mortality within 3 months | ||||||||||||
| 3 | Observational studies | Serious a | Not serious | Not serious | Serious c | None | 30/2014 (1.5%) | 10/539 (1.9%) | OR 0.80 (0.38–1.68) | Four fewer per 1000 (from 11 fewer to 12 more) | ⨁◯◯◯ Very low | Critical |
| Periprocedural stroke | ||||||||||||
| 3 | Observational studies | Serious a | Not serious | Serious b | Serious c | None | 300/2014 (14.9%) | 46/539 (8.5%) | OR 1.49 (0.59–3.75) | 37 more per 1000 (from 33 fewer to 174 more) | ⨁◯◯◯ Very low | Critical |
CI: confidence interval; OR: odds ratio.
a
All studies rated serious with Robins-I tool.
b
Outcomes had various definitions across studies.
c
Confidence interval unable to exclude substantial benefit or harm.