Table 3.
GRADE evidence profile table for PICO 4.
| Certainty assessment | No. of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Angioplasty and/or stenting plus Best Medical Therapy (BMT) after initial mechanical thrombectomy | BMT alone | Relative (95% CI) | Absolute (95% CI) | ||
| Good functional outcome (mRS 0–2) at 90 days | ||||||||||||
| 3 | Observational studies | Serious a | Serious b | Serious c | Serious d | None | 97/159 (61.0%) | 88/200 (44.0%) | OR 2.18 (1.37–3.46) | 191 more per 1000 (from 78 more to 291 more) | ⨁◯◯◯Very low | CRITICAL |
| Good functional outcome (mRS 0–2) at 90 days (sensitivity analysis: Baek et al. intervention group is rescue stenting + mechanical thrombectomy) | ||||||||||||
| 3 | Observational studies | Serious a | Not serious | Serious c | Not serious | None | 54/108 (50.0%) | 33/118 (28.0%) | OR 2.43 (1.38–4.30) | 206 more per 1000 (from 69 more to 346 more) | ⨁◯◯◯Very low | CRITICAL |
| Symptomatic ICH | ||||||||||||
| 3 | Observational studies | Serious a | Not serious | Serious c | Serious e | None | 12/134 (9.0%) | 20/118 (16.9%) | OR 0.56 (0.26–1.22) | 67 fewer per 1000 (from 119 fewer to 30 more) | ⨁◯◯◯Very low | CRITICAL |
| Mortality at 90 days | ||||||||||||
| 3 | Observational studies | Serious a | Not serious | Serious c | Not serious | None | 26/134 (19.4%) | 43/118 (36.4%) | OR 0.52 (0.28–0.95) | 135 fewer per 1000 (from 226 fewer to 12 fewer) | ⨁◯◯◯Very low | CRITICAL |
CI: confidence interval; OR: odds ratio.
a
Some or all included studies have a serious risk of bias as assessed with Robins-I.
b
Statistical heterogeneity.
c
Intervention/comparator dissimilarity.
d
Wide confidence interval.
e
Confidence interval unable to exclude substantial benefit or harm.